Human T-lymphotropic virus type I among blood donors from Guadeloupe: donation, demographic, and biologic characteristics.
Transfusion
; 39(6): 639-44, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10378845
ABSTRACT
BACKGROUND:
Epidemiologic data on human T-lymphotropic virus type I (HTLV-I) in Guadeloupe (French West Indies) are scant. STUDY DESIGN ANDMETHODS:
From January 1989 to December 1996, 59,426 blood donors were screened by enzyme immunoassay for antibodies to HTLV-I. All repeatedly reactive samples were confirmed by Western blot. Temporal trends in HTLV-I seropositivity rates were examined during the study period. A multivariate analysis of donation, demographic, and biologic characteristics was performed.RESULTS:
Of the screened blood donors, 195 were confirmed as seropositive, for an overall prevalence of 0.33 percent (95% CI 0.28-0.38). A marked decrease in overall HTLV-I prevalence with time (from 0.47% in 1989 to 0.13% in 1996) was observed, which can be explained mainly by the decreasing percentage of recruited new donors during the study period. Four independent risk factors for HTLV-I were identified new donor status (odds ratio [OR] 12.5), female sex (OR 1.7), increasing age (30-39 years OR, 2.4; 40-49 years OR, 3.7; >50 years OR 6.6), and positive antibodies to hepatitis B virus core antigen (OR, 1.7). Selection of specific locations for blood collection was inversely associated with HTLV-I (OR 0.5).CONCLUSION:
New donor status, advancing age, female sex, and positivity for hepatitis B virus core antibodies were the major factors associated with HTLV-I infection in Guadeloupe.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Donantes de Sangre
/
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Caribe
/
Guadalupe
Idioma:
En
Revista:
Transfusion
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia