The influence of individual susceptibility in pyrethroid exposure.
Toxicol Lett
; 107(1-3): 123-30, 1999 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-10414789
ABSTRACT
The aim of this study was to find a suitable biomarker for pyrethroid adverse effects. It was shown that there is a correlation between the half-life time (t(1/2)) of pyrethroids in plasma and the clinical findings. We hypothized that this finding indicates an interindividual different amount of total esterase activity or even a polymorphism. By in vitro experiments it was demonstrated that pyrethroids are cleaved by carboxylesterases. After it turned out that carboxylesterase activity in human plasma is too low for detection, a method for specific determination of carboxylesterase activity in human isolated lymphocytes was developed. As a substrate for carboxylesterase activity, cyfluthrin was added to the lymphocyte suspension. As a proof for cyfluthrin degradation by carboxylesterases the produced hydrocyanic acid was determined by GC/MS. First hints for interindividual differences in carboxylesterase activity in lymphocytes were found.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piretrinas
/
Insecticidas
Límite:
Humans
/
Male
Idioma:
En
Revista:
Toxicol Lett
Año:
1999
Tipo del documento:
Article
Pais de publicación:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS