Activity of cytochrome c oxidase in the right and left ventricular myocardium of male and female rats exposed to intermittent high altitude hypoxia.
Ann N Y Acad Sci
; 874: 269-77, 1999 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-10415538
ABSTRACT
The aim of the present study was to compare the capacity of the oxidative metabolism (total activity of cytochrome c oxidase, COX) in the right and left ventricular myocardium of adult rats exposed to intermittent high altitude (IHA) hypoxia simulated in a barochamber (5,000 m, 8 h/day, 5 days/wk, for a total of 32 exposures). In male and female rats, IHA induced significant increases of the right ventricular (RV) weight and protein content, whereas left ventricular (LV) weight and protein content remained unaffected. Consequently, the RV/LV ratio in both sexes markedly increased. Similarly, IHA induced an increase of the total activity of COX in RV in both sexes. The specific activities of COX in homogenate as well as in isolated mitochondria were not changed in IHA-exposed animals, which indicates that the increase of total activity of COX is proportional to the increase of total protein content and RV weight.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Función Ventricular Izquierda
/
Función Ventricular Derecha
/
Complejo IV de Transporte de Electrones
/
Altitud
/
Hipoxia
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
1999
Tipo del documento:
Article
País de afiliación:
República Checa