Thymidine phosphorylase activity and angiogenesis in gastric cancer.

Kakeji, Y; Maehara, Y; Tomoda, M; Kabashima, A; Oda, S; Ooshiro, T; Baba, H; Kohnoe, S; Sugimachi, K

Kakeji, Y; Maehara, Y; Tomoda, M; Kabashima, A; Oda, S; Ooshiro, T; Baba, H; Kohnoe, S; Sugimachi, K.

Afiliación

Kakeji Y; Department of Surgery II, Faculty of Medicine, Kyushu University, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

Oncol Rep ; 6(5): 995-9, 1999.

Article en En | MEDLINE | ID: mdl-10425293

ABSTRACT

ABSTRACT

Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.

Asunto(s)

Neovascularización Patológica/enzimología; Neoplasias Gástricas/irrigación sanguínea; Neoplasias Gástricas/enzimología; Timidina Fosforilasa/metabolismo; Adulto; Anciano; Cromatografía Liquida; Femenino; Humanos; Masculino; Persona de Mediana Edad; Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo; Estudios Prospectivos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Timidina Fosforilasa / Neovascularización Patológica Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 1999 Tipo del documento: Article País de afiliación: Japón

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