Preparation and antibiotic activity of monobactam analogues of nocardicins.
Prep Biochem Biotechnol
; 29(3): 257-72, 1999 Aug.
Article
en En
| MEDLINE
| ID: mdl-10431930
ABSTRACT
A series of diverse beta-lactam analogues of nocardicins with interesting antimicrobial properties were prepared. Coupling of glucosamine to these compounds improved their water solubility. Aminoacid derivatives produced a stereoinduction on the quaternary enantiotopic carbon of the starting compound 1. Evaluation of their antimicrobial activity showed that the introduction of alpha-amninoacids to monobactams increased their activity. The importance of asymmetric carbon is exemplified by the higher antibiotic activity of L-alpha-aminoacids than the D-series. No significant difference was observed between fluorinated and non-fluorinated monobactams.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Monobactamas
/
Bacterias Gramnegativas
/
Bacterias Grampositivas
/
Lactamas
Idioma:
En
Revista:
Prep Biochem Biotechnol
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia