Suitability of the old fowl rectal caecum preparation for investigating the selectivity of beta-adrenergic drugs.
J Pharmacol Toxicol Methods
; 40(4): 221-5, 1998 Nov.
Article
en En
| MEDLINE
| ID: mdl-10465157
ABSTRACT
We tested alpha- and beta-adrenergic drugs on isolated strips of fowl rectal caecum from 14- to 16-week-old Warren hens. Basal tone and spontaneous motility were dose-dependently reduced by isoprenaline and all the selective beta-agonists tested (except xamoterol) with the following order of potency isoprenaline=fenoterol=procaterol=clenbuterol>dobutamine> SR58611A. The results indicate that this tissue preparation consists almost entirely of beta2-adrenoceptors. This preparation may, therefore, be considered a suitable assay for discriminating beta1- from beta2-agonists according to their selectivity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciego
/
Agonistas alfa-Adrenérgicos
/
Agonistas Adrenérgicos beta
/
Motilidad Gastrointestinal
/
Contracción Muscular
Límite:
Animals
Idioma:
En
Revista:
J Pharmacol Toxicol Methods
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia