Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis.
FEBS Lett
; 457(3): 470-4, 1999 Sep 03.
Article
en En
| MEDLINE
| ID: mdl-10471831
ABSTRACT
Here we report the functional importance of profilin in various actin-mediated morphological changes using H119E mutant profilin I, which is deficient only in actin binding. In the case of actin-protrusive structures from the plasma membrane, H119E-profilin was shown to suppress the formation of Cdc42-induced actin microspikes and Rac-induced membrane ruffles. Conversely, Rho-induced stress fiber formation seemed to occur independently of H119E-profilin introduction. Furthermore, H119E-profilin blocked cleavage furrow ingression and subsequent adhesion to the substratum during cell division, a process in which actin plays indispensable roles.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células HeLa
/
Membrana Celular
/
Actinas
/
Células 3T3
/
Proteínas Contráctiles
/
Proteínas de Microfilamentos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón