Cystoid macular edema after cataract surgery with intraocular vancomycin.
Ophthalmology
; 106(9): 1660-4, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10485531
ABSTRACT
OBJECTIVE:
To determine whether the use of supplemental prophylactic vancomycin in the irrigating solution during extracapsular lens extraction is associated with increased incidence of cystoid macular edema.DESIGN:
Prospective, randomized, double-masked clinical study.PARTICIPANTS:
Consecutive series of 118 patients 60 years of age or older undergoing cataract surgery. INTERVENTION The study group received an irrigating balanced salt solution supplemented with vancomycin (10 microg/ml), and the control group received the salt solution only. Fluorescein angiography was performed 1 and 4 months after surgery. MAIN OUTCOMEMEASURES:
Evidence of angiographic and clinical cystoid macular edema, and visual acuity at 1 and 4 months after surgery.RESULTS:
The rate of postoperative angiographic cystoid macular edema was significantly higher in the study patients than in the control group at 1 month (55% vs. 19%, P = 0.0006) and 4 months (26% vs. 4%, P = 0.0099). The rates of clinical macular edema were 23% and 7%, respectively, at 1 month (P = 0.011) and 20% versus 0% at 4 months (P = 0.006). Visual acuity of 20/30 or better was noted at 4 months after surgery in 76% of the study group compared to 95.5% of the control group.CONCLUSIONS:
The role of preventive intracameral vancomycin during intraocular surgery should be reassessed in view of the associated increase in the incidence of angiographic cystoid macular edema.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vancomicina
/
Extracción de Catarata
/
Edema Macular
/
Antibacterianos
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ophthalmology
Año:
1999
Tipo del documento:
Article
País de afiliación:
Israel