Changes in hepatic microcirculation and histomorphology in brain-dead organ donors: an experimental study in rats.
Eur J Surg
; 165(8): 759-66, 1999 Aug.
Article
en En
| MEDLINE
| ID: mdl-10494642
ABSTRACT
OBJECTIVE:
To assess the effect of brain death on hormonal homeostasis, hepatic microcirculation, and histomorphology in organ donors.DESIGN:
Prospective randomised experimental study.SETTING:
Institute for Surgical Research, Germany.SUBJECTS:
12 male Sprague-Dawley ratsINTERVENTIONS:
6 rats acted as controls, and 6 had brain death induced by inflation of an intracranial balloon. MAIN OUTCOMEMEASURES:
Mean arterial pressure, serum concentration of antidiuretic hormone (ADH), thyroxine (T4), free-T4, triiodothyronine (T3) and free-T3, bile production, intravital fluorescence microscopy and electron microscopic appearances.RESULTS:
After induction of brain death mean arterial pressure rose within 5 minutes followed by significant hypotension (p < 0.01). ADH concentration was reduced (p < 0.01), as was bile production (p < 0.05). There was impaired sinusoidal perfusion and increased interaction between leucocytes and endothelium in the hepatic microvasculature. The electron microscopic analysis showed vacuolisation of hepatocytes.CONCLUSION:
Macrohaemodynamics, ADH homeostasis, and the hepatic microcirculation deteriorate after brain death, which leads to histomorphological damage of hepatocytes and compromised liver function.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Donantes de Tejidos
/
Muerte Encefálica
/
Hígado
/
Circulación Hepática
Límite:
Animals
Idioma:
En
Revista:
Eur J Surg
Año:
1999
Tipo del documento:
Article
País de afiliación:
Alemania