Novel benzo-fused lactam scaffolds as factor Xa inhibitors.
Bioorg Med Chem Lett
; 9(17): 2573-8, 1999 Sep 06.
Article
en En
| MEDLINE
| ID: mdl-10498211
ABSTRACT
Rigid benzolactam P3-P2 dipeptide mimics were designed and prepared as potential inhibitors of blood coagulation factor Xa. Methoxy substitution of the tetrahydrobenzazepinone scaffold led to potent and selective inhibitors. The synthesis and biological activities of these derivatives are reported herein.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Serina Proteinasa
/
Inhibidores del Factor Xa
/
Lactamas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos