P53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 88(3): 326-32, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10503863
ABSTRACT
OBJECTIVE:
Recent epidemiologic studies have identified a trend of increasing cancer incidence in younger patients. The purpose of this study was to determine whether this might be reflected by different molecular mechanisms for tumor development. STUDYDESIGN:
Dysplastic and malignant oral lesions from age-distinct patient populations were immunohistochemically analyzed for expression of p53 and cyclin D1. Chi-square analysis was used to determine statistical significance.RESULTS:
Eighty-two percent of "older" and 75% of "younger" carcinomas stained positively with p53; 63% of carcinomas in the older population and 55% of carcinomas in the younger population showed cyclin D1 positivity. Dysplasias showed similar cyclin D1 staining in both groups. Interestingly, 100% of "younger" dysplasias stained positively for p53, whereas 35.3% of "older" dysplastic lesions showed immunoreactivity. Staining of carcinomas was not statistically significant, whereas p53 staining of dysplasias proved highly significant (P < .025).CONCLUSIONS:
p53 immunoreactivity is detectable at an earlier stage of carcinogenesis in younger patients than in the traditional risk population for oral cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Proteína p53 Supresora de Tumor
/
Ciclina D1
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos