Altered surfactant protein B levels in transgenic mice do not affect clearance of bacteria from the lungs.
Pediatr Res
; 46(5): 530-4, 1999 Nov.
Article
en En
| MEDLINE
| ID: mdl-10541314
ABSTRACT
To determine the role of surfactant protein B (SP-B) in bacterial clearance from the airways, three groups of mice expressing different levels of SP-B were studied wild-type mice, hemizygous SP-B mice, and SP-B overexpressing transgenic mice. SP-B levels in overexpressing mice were increased 5-fold relative to hemizygous mice and 2- to 3-fold over wild-type littermates. Mice from each group were infected intratracheally with the common airway pathogens, group B streptococci or Pseudomonas aeruginosa. There was no significant difference in the number of recoverable viable bacteria at 6 h (group B streptococci and P. aeruginosa) and at 24 h (P. aeruginosa) among the three groups. Similarly, systemic dissemination of bacteria was not different among the three groups for both pathogens and at both time points. We conclude that SP-B levels in vivo do not influence clearance of bacteria from the lungs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteolípidos
/
Pseudomonas aeruginosa
/
Streptococcus agalactiae
/
Surfactantes Pulmonares
/
Pulmón
Límite:
Animals
Idioma:
En
Revista:
Pediatr Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos