Transcription factors regulating pituitary development.
Growth Horm IGF Res
; 9 Suppl B: 2-8; discussion 8-11, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10549299
ABSTRACT
This review will address contributions of nuclear transcription factors to the embryologic development and definitive function of the anterior pituitary gland. The HESX1, PITX1, PITX2, PROP1 and POU1F1 genes are of particular interest because of their recognized or potential associations with human disease. Mutations of any of the first three genes produce complex disease phenotypes such as septo-optic dysplasia, Treacher Collins Franceschetti syndrome or Rieger syndrome that may include deficiency of one or more pituitary hormones. Mutations in PROP1 or POU1F1, or their mouse homologous, result in severe hypopituitarism as well as morphological abnormalities of the pituitary gland.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipófisis
/
Factores de Transcripción
/
Proteínas Nucleares
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Growth Horm IGF Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos