[Clinical effectiveness of degradable starch microspheres (DSM) in patients with liver cancer].
Gan To Kagaku Ryoho
; 26(12): 1678-83, 1999 Oct.
Article
en Ja
| MEDLINE
| ID: mdl-10560370
Recently, degradable starch microspheres (DSM) have become available for use in patients with liver cancer in Japan. When DSM combined with a cytotoxic drug are infused through the hepatic artery, the steep drug concentration gradient to the tumor tissue results in a higher tissue drug concentration, which may elicit an increased antitumor response by blocking regional blood flow. Furthermore, the reduced systemic exposure of a coinjected drug can be translated into an increased regional extraction ratio due to blood flow reduction. DSM is infused via a catheter connecting to a subcutaneously implanted reservoir in outpatients. Pain is experienced by all patients. Other frequently observed adverse reactions are nausea and vomiting. However, these symptoms improve within a few hours. These observations indicate that intra-arterial chemotherapy combined with DSM may provide a more potent anticancer effect than a cytotoxic drug alone.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bombas de Infusión Implantables
/
Quimioembolización Terapéutica
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Límite:
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Japón