Your browser doesn't support javascript.
loading
[Clinical effectiveness of degradable starch microspheres (DSM) in patients with liver cancer].
Kumada, T; Nakano, S; Sone, Y; Kiriyama, S; Hisanaga, Y; Rikitoku, T; Tamoto, A; Honda, T.
Afiliación
  • Kumada T; Dept. of Gastroenterology, Ogaki Municipal Hospital.
Gan To Kagaku Ryoho ; 26(12): 1678-83, 1999 Oct.
Article en Ja | MEDLINE | ID: mdl-10560370
Recently, degradable starch microspheres (DSM) have become available for use in patients with liver cancer in Japan. When DSM combined with a cytotoxic drug are infused through the hepatic artery, the steep drug concentration gradient to the tumor tissue results in a higher tissue drug concentration, which may elicit an increased antitumor response by blocking regional blood flow. Furthermore, the reduced systemic exposure of a coinjected drug can be translated into an increased regional extraction ratio due to blood flow reduction. DSM is infused via a catheter connecting to a subcutaneously implanted reservoir in outpatients. Pain is experienced by all patients. Other frequently observed adverse reactions are nausea and vomiting. However, these symptoms improve within a few hours. These observations indicate that intra-arterial chemotherapy combined with DSM may provide a more potent anticancer effect than a cytotoxic drug alone.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombas de Infusión Implantables / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: Ja Revista: Gan To Kagaku Ryoho Año: 1999 Tipo del documento: Article Pais de publicación: Japón
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombas de Infusión Implantables / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: Ja Revista: Gan To Kagaku Ryoho Año: 1999 Tipo del documento: Article Pais de publicación: Japón