[The anti-ischemic effects of 3-hydroxypyridine derivatives in cerebrovascular pathology]. / Protivoishemicheskie éffekty proizvodnykh 3-oksipiridina pri tserebrovaskuliarnoi patologii.
Eksp Klin Farmakol
; 62(5): 15-7, 1999.
Article
en Ru
| MEDLINE
| ID: mdl-10572744
ABSTRACT
The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Picolinas
/
Piridinas
/
Isquemia Encefálica
/
Antioxidantes
Límite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Rusia