Melatonin activates Th1 lymphocytes by increasing IL-12 production.
Life Sci
; 65(20): 2143-50, 1999.
Article
en En
| MEDLINE
| ID: mdl-10579467
ABSTRACT
Melatonin could act on immune system by regulating cytokine production of immunocompetent cells. The hormone enhances IL-2, IFN-gamma and IL-6 production by cultured human mononuclear cells. As enhancement of IL-6 production is related to monocyte activation by melatonin, the hormone acts on human lymphoid cells causing a Th1-type response. This paper shows that melatonin seems to promote a Th1-response by increasing IL-12 production. The hormone enhances IL-12 production by cultured monocytes under suboptimal stimulation in a dose-dependent way. The effect of the hormone increases when PBMCs are incubated with melatonin before monocyte isolation. Enhanced IL-12 production by melatonin can also be shown in cultured human mononuclear cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Células TH1
/
Interleucina-12
/
Melatonina
Límite:
Humans
Idioma:
En
Revista:
Life Sci
Año:
1999
Tipo del documento:
Article
País de afiliación:
España