Serum concentration and renal handling of 1,5-anhydro-D-glucitol in patients with chronic renal failure.
Ann Clin Biochem
; 36 ( Pt 6): 749-54, 1999 Nov.
Article
en En
| MEDLINE
| ID: mdl-10586312
ABSTRACT
We measured serum and urinary 1,5-anhydro-D-glucitol (1,5-AG) during a glucose tolerance test (GTT) in patients with chronic renal failure (CRF) and compared the fractional excretion of 1,5-AG (FEAG) with that of diabetes mellitus (DM) patients and healthy controls. The mean serum 1,5-AG in CRF patients [60 +/- 23(SE) mumol/L] was significantly lower than in controls (155 +/- 7 mumol/L) in spite of a normal glycaemia. The levels in the CRF group were similar to those in the DM group. During GTT, the blood glucose profile in the CRF group was not significantly different from that of the control group, and urinary glucose excretion was negligible. However, FEAG was significantly higher in CRF patients than in controls. These data suggest that serum 1,5-AG in patients with CRF decreases due to a decrease in 1,5-AG reabsorption, independently of glucose excretion, and that serum and/or urinary 1,5-AG can be a useful marker for renal tubular dysfunction because the 1,5-AG reabsorption system is more vulnerable than the glucose reabsorption system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desoxiglucosa
/
Fallo Renal Crónico
Límite:
Humans
Idioma:
En
Revista:
Ann Clin Biochem
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón