Inhibitory effect of piceatannol, a protein tyrosine kinase inhibitor, on asexual maturation of Plasmodium falciparum.
Indian J Exp Biol
; 37(4): 418-20, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10641182
ABSTRACT
This report describes the effect of piceatannol (3,4,3',5'-tetrahydroxy trans stilbene), a plant secondary natural product, on protein tyrosine kinase (PTK) activity in different stages of P. falciparum grown in vitro. Piceatannol inhibited PTK activity in trophozoites and schizonts suggesting that PTK may be important in the initial asexual maturation of the parasite. Inhibition of PTK activity by piceatannol may thus provide new insights into more specific tools for chemotherapeutic interventions for P. falciparum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Estilbenos
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Indian J Exp Biol
Año:
1999
Tipo del documento:
Article
País de afiliación:
India