Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection.
Eur J Immunol
; 30(2): 709-13, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10671231
ABSTRACT
Apoptosis plays a critical role in T cell development and thymic selection. Thymocytes which undergo antigen-induced negative selection have been demonstrated to die by apoptosis. Despite this, relatively little is known about the specific apoptotic pathway involved in negative selection. We have examined the role of cyclin-dependent kinase 2 (Cdk2), a key regulator of thymocyte apoptosis, in this process. Stimulation of thymocytes with cognate antigen leads to a large increase in Cdk2 kinase activity. We also show that pharmacological inhibitors of Cdk2 block thymocyte apoptosis in response to antigen. Our data show that Cdk2 activity is essential for the apoptotic pathway used in negative selection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Linfocitos T
/
Proteínas Serina-Treonina Quinasas
/
Apoptosis
/
Quinasas Ciclina-Dependientes
/
Quinasas CDC2-CDC28
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido