Therapeutic effects of parenteral beta-lactam antibiotics on experimental otitis media caused by penicillin-resistant Streptococcus pneumoniae in guinea-pigs.
J Antimicrob Chemother
; 45(3): 311-4, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10702549
ABSTRACT
The therapeutic effects of parenteral beta-lactam antibiotics were evaluated in experimental acute otitis media caused by penicillin-resistant Streptococcus pneumoniae (PRSP) in guinea-pigs. Cefotaxime, ceftriaxone and piperacillin significantly reduced viable cell counts of PRSP in the middle ear at a dose of 50 mg/kg bd for 3 days (P < 0.01 compared with control). The therapeutic effects of cefotaxime, ceftriaxone and piperacillin were superior to those of cefotiam and ceftazidime. These therapeutic effects reflected both in vitro activity and pharmacokinetic properties of the drugs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Otitis Media
/
Infecciones Estreptocócicas
/
Streptococcus pneumoniae
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón