Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring.
Br J Ophthalmol
; 84(4): 408-12, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10729300
ABSTRACT
AIM:
To determine the relative impact of CD4+ T cells and CD8+ T cells in protecting mice against ocular HSV-1 challenge.METHODS:
CD4+ T cell knockout mice (CD4-/- mice), CD8+ T cell knockout mice (CD8-/- mice), and mice depleted for CD4+ or CD8+ T cells by antibody (CD4+ depleted and CD8+ depleted mice), were examined for their ability to withstand HSV-1 ocular challenge. The parental mice for both knockout mice were C57BL/6J.RESULTS:
These results suggest that (1) both CD4+ deficient mice (CD4-/- and CD4+ depleted mice) and CD8+ deficient mice (CD8-/-, and CD8+ depleted mice) developed significantly more corneal scarring than their C57BL/6J parental strain; (2) the duration of virus clearance from the eyes of the CD4+ deficient mice was 4 days longer than that of the CD8+ deficient mice; and (3) the severity of corneal scarring in the CD4+ deficient mice was approximately twice that of the CD8+ deficient mice.CONCLUSIONS:
It was reported here that (1) CD4+ and CD8+ T cells were both involved in protection against lethal ocular HSV-1 infection; and (2) CD4+ and CD8+ T cells were both involved in protection against HSV-1 induced corneal scarring.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Queratitis Herpética
/
Herpesvirus Humano 1
/
Linfocitos T CD8-positivos
Límite:
Animals
Idioma:
En
Revista:
Br J Ophthalmol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos