A whole-genome assembly of Drosophila.
Science
; 287(5461): 2196-204, 2000 Mar 24.
Article
en En
| MEDLINE
| ID: mdl-10731133
ABSTRACT
We report on the quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it. Three independent external data sources essentially agree with and support the assembly's sequence and ordering of contigs across the euchromatic portion of the genome. In addition, there are isolated contigs that we believe represent nonrepetitive pockets within the heterochromatin of the centromeres. Comparison with a previously sequenced 2.9- megabase region indicates that sequencing accuracy within nonrepetitive segments is greater than 99. 99% without manual curation. As such, this initial reconstruction of the Drosophila sequence should be of substantial value to the scientific community.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Genoma
/
Análisis de Secuencia de ADN
/
Biología Computacional
/
Drosophila melanogaster
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos