Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein.
Vaccine
; 18(22): 2426-34, 2000 May 08.
Article
en En
| MEDLINE
| ID: mdl-10738100
ABSTRACT
Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Virales
/
Proteínas del Envoltorio Viral
/
Vacunas de ADN
/
Virus del Dengue
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vaccine
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos