Ropivacaine-clonidine combination for caudal blockade in children.
Acta Anaesthesiol Scand
; 44(4): 446-9, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10757579
ABSTRACT
BACKGROUND:
Adding clonidine to weak ropivacaine solutions (<0.2%) could potentially enhance analgesia as well as further reduce the risk for unwanted motor blockade. The aim of the present study was to compare the postoperative pain-relieving quality of a ropivacaine 0.1%-clonidine mixture to that of plain ropivacaine 0.2% following caudal administration in children.METHODS:
In a prospective, observer-blinded fashion, 40 ASA 1 paediatric patients undergoing subumbilical surgery were randomly allocated to receive a caudal injection of either plain ropivacaine 0.2% (1 ml/kg) (R0.2) or a mixture of ropivacaine 0.1% with clonidine 2 microg/kg (1 ml/kg) (R0.1C). Objective pain scale score and need for supplemental analgesia were used to evaluate analgesia during the first 24 h postoperatively. Residual postoperative sedation was also assessed.RESULTS:
A significantly higher number of patients in the R0.1C group (18/20) could be managed without supplemental analgesia during the first 24 h postoperatively compared to the R0.2 group (11/20) (P=0.034). Both the degree and the duration of postoperative sedation was similar in both groups. No signs of postoperative motor blockade were observed.CONCLUSIONS:
The combination of clonidine (2 microg/kg) and ropivacaine 0.1% is associated with an improved quality of postoperative analgesia compared to plain 0.2% ropivacaine. The improved analgesic quality of the clonidine-ropivacaine mixture is achieved without causing any significant degree of postoperative sedation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Clonidina
/
Agonistas alfa-Adrenérgicos
/
Amidas
/
Adyuvantes Anestésicos
/
Anestesia Caudal
/
Anestésicos Locales
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Acta Anaesthesiol Scand
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia