The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection.
Am J Gastroenterol
; 95(4): 947-55, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10763943
ABSTRACT
OBJECTIVE:
Omeprazole produces a higher intragastric pH during Helicobacter pylori (H. pylori) infection than after cure. We tested the hypothesis that this difference is due to the production of ammonia by H. pylori.METHODS:
Gastric acidity and acid output (AO) were measured overnight in 12 subjects, with and without omeprazole, before and 1 and 6 months after cure of H. pylori infection. Gastric ammonia ([NH3]), total bile acid ([TBA]) and protein concentrations and plasma omeprazole levels were measured.RESULTS:
During omeprazole, median AO were 0.0 mmol/h before, 0.86 mmol/h (p = 0.003 vs before cure) at 1 month, and 0.34 mmol/h (p = 0.02) at 6 months after cure; median NH3 output was 0.17 mmol/h before, 0.03 mmol/h (p = 0.002) at 1 month, and 0.02 mmol/h (p = 0.005) at 6 months after cure. AO and NH3 output were similar 1 and 6 months after cure. When corrected for [NH3], AO and gastric pH curves were similar before and after cure. Omeprazole plasma levels increased after cure and gastric [TBA] were unchanged.CONCLUSIONS:
The higher pH observed before cure of H. pylori during omeprazole administration is attributable, in large part, to ammonia production. Other acid-neutralizing substances and changes in acid secretion may also be important, but duodenogastric reflux and omeprazole pharmacokinetics are not involved.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Determinación de la Acidez Gástrica
/
Gastritis
/
Amoníaco
/
Antiulcerosos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Suiza