Agnoprotein 1a and agnoprotein 1b of avian polyomavirus are apoptotic inducers.
J Gen Virol
; 81(Pt 5): 1183-90, 2000 May.
Article
en En
| MEDLINE
| ID: mdl-10769059
ABSTRACT
Avian polyomavirus (APV) causes an acute fatal disease in a variety of avian species. DNA laddering indicating apoptosis was demonstrated in APV-infected chicken embryo (CE) cells. DNA laddering, however, was not observed in Vero cells infected with mammalian polyomavirus simian virus 40. Expression of APV agnoprotein 1a and agnoprotein 1b induced apoptosis in insect cells and CE cells. An APV full-length plasmid transfected in CE cells induced apoptosis, and infectious virus was produced. After transfection of CE cells with a plasmid containing a mutated initiation codon for agnoprotein 1a and agnoprotein 1b, however, a considerably lower number of apoptotic cells was observed, and no infectious progeny was produced.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Apoptosis
/
Poliomavirus
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania