Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody.
Microbiol Immunol
; 44(3): 197-200, 2000.
Article
en En
| MEDLINE
| ID: mdl-10789508
ABSTRACT
Previously, we reported that the consecutive administration of lipopolysaccharide (LPS) into LPS-sensitized mice for the generalized Shwartzman reaction (GSR) induced systemic injury of vascular endothelial cells. The aim of this study was to investigate the participation of vascular adhesion molecules in the vascular endothelial injury of GSR. The administration of anti-E-selectin antibody in GSR-induced mice resulted in massive apoptosis of vascular endothelial cells and congestion in blood vessels. Further, marked hemorrhage was found in the pulmonary alveoli of those mice. GSR, especially lung injury, was definitely exacerbated by the administration of anti-E-selectin antibody. On the other hand, the administration of anti-VCAM-1 antibody did not induce such injury of vascular endothelial cells. The possible role of E-selectin in the exacerbation of vascular endothelial injury in GSR is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenómeno de Shwartzman
/
Endotelio Vascular
/
Lipopolisacáridos
/
Selectina E
Límite:
Animals
Idioma:
En
Revista:
Microbiol Immunol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón