Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
J Org Chem
; 65(1): 124-8, 2000 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-10813905
ABSTRACT
Four novel anti-HIV macrocyclic peptides containing 28-31 amino acid residues, named cycloviolins A-D, have been isolated from the hitherto unstudied tropical plant Leonia cymosa. Their primary structure, including amino acid composition and sequence, was determined by a combination of MALDI-TOF and FAB MS and by enzymatic digestion of reduced derivatives, followed by Edman degradation and mass analyses. All of the cycloviolins contain six cysteines, which are present as three intramolecular disulfide bridges. Intriguingly, cycloviolins A-D showed high degrees of sequence homology to the known cyclopsychotride A and circulins A and B from the Rubiaceae family but much less homology to the varv peptides from Viola, a member of the same family (Violaceae).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Plantas
/
Fármacos Anti-VIH
Idioma:
En
Revista:
J Org Chem
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos