Carvedilol affects the physiological and behavioral response to smoked cocaine in humans.
Drug Alcohol Depend
; 60(1): 69-76, 2000 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-10821991
ABSTRACT
The noradrenergic system is implicated in mediating some of the physiological effects of cocaine. The purpose of this study was to investigate whether treatment with an adrenergic blocker, carvedilol, which would be expected to attenuate the physiological effects of cocaine, would also attenuate the subjective and behavioral response to cocaine in humans. Twelve crack cocaine users participated in this double-blind, placebo-controlled outpatient study. Acute treatment with 50 mg of oral carvedilol attenuated the smoked cocaine-induced increases in heart rate, systolic and diastolic blood pressure. The number of cocaine self-administrations was lower under 25 mg carvedilol treatment condition compared with 50 mg carvedilol or placebo treatment conditions. The subjective responses to smoked cocaine deliveries were not affected by carvedilol treatment. These results suggest that acute treatment with carvedilol attenuates the physiological effects of smoked cocaine. The effects of carvedilol on cocaine self-administration need to be studied further.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propanolaminas
/
Carbazoles
/
Cocaína
/
Inhibidores de Captación de Dopamina
/
Antagonistas Adrenérgicos
/
Trastornos Relacionados con Cocaína
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Drug Alcohol Depend
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos