Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor.
Ann Intern Med
; 132(11): 880-4, 2000 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-10836914
ABSTRACT
BACKGROUND:
Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause tissue edema in humans has not been established.OBJECTIVE:
To evaluate patients undergoing VEGF gene transfer for evidence of lower-extremity edema.DESIGN:
Prospective consecutive case series.SETTING:
Hospital outpatient clinic. PATIENTS 62 patients with critical limb ischemia and 28 patients with claudication. INTERVENTION Gene transfer of VEGF DNA. MEASUREMENTS Semiquantitative analysis of lower-extremity edema.RESULTS:
Lower-extremity edema was observed in 31 of 90 (34%) patients. Edema was less common in patients with claudication than in those with pain at rest (P = 0.016) or ischemic ulcers (P < 0.001), and it was less common in patients with pain at rest than in those with ischemic ulcers (P= 0.017). Treatment was typically limited to a brief course of oral diuretics.CONCLUSIONS:
Vascular endothelial growth factor may enhance vascular permeability in humans. At the doses of plasmid DNA used in this study, lower-extremity edema responded to oral diuretic therapy and did not seem to be associated with serious sequelae.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Factores de Crecimiento Endotelial
/
Linfocinas
/
Enfermedades Vasculares Periféricas
/
Técnicas de Transferencia de Gen
/
Isoformas de Proteínas
/
Edema
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
Ann Intern Med
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos