Pharmacokinetics of miocamycin following intravenous administration to cattle.
J Vet Med A Physiol Pathol Clin Med
; 47(1): 37-41, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10841461
ABSTRACT
The plasma pharmacokinetics for a single intravenous dose (10 mg/kg body weight) of miocamycin (a 16-membered macrolide drug) was investigated in Holando Argentino cattle (n = 5). Blood drug concentrations were determined by a microbiological method and data were best-fitted to a two-compartment open model. The pharmacokinetic profile consisted of a short distribution phase (t1/2 alpha = 7.41 +/- 0.53 min), followed by an extended terminal elimination phase (t1/2 beta = 2.49 +/- 0.23 h). The volume of distribution at steady-state was large (2.13 +/- 0.17 l/kg), suggesting extensive tissue distribution, the clearance value was 0.60 +/- 0.03 l/h.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bovinos
/
Miocamicina
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Med A Physiol Pathol Clin Med
Año:
2000
Tipo del documento:
Article
País de afiliación:
España