Response of jejunal Na+, K+-ATPase to 5-hydroxytryptamine in young and adult rats: effect of fasting and refeeding.
Acta Physiol Scand
; 169(2): 167-72, 2000 Jun.
Article
en En
| MEDLINE
| ID: mdl-10848647
ABSTRACT
The present study is aimed to evaluate the effects of 5-hydroxytryptamine (5-HT) upon jejunal Na+,K+-ATPase in young (20-day-old) and adult (60-day-old) rats, and determine the effect of food intake on the response of the sodium pump to the amine. Basal Na+,K+-ATPase activity in jejunal epithelial cells from young rats was twice that in adult animals and responded to 5-HT with stimulation. In adult rats, fasting reduced by 25% basal jejunal Na+, K+-ATPase activity, whereas in young rats, no such change was observed. The sensitivity of jejunal Na+,K+-ATPase to 5-HT in young fasted rats was similar to that observed in fed animals. The effect of refeeding in young rats was a 2-fold increase in jejunal Na+, K+-ATPase activity, this being accompanied by insensitivity to 5-HT. In adult rats, refeeding was accompanied by an increase in jejunal Na+,K+-ATPase activity. It is concluded that the stimulatory effect of 5-HT upon jejunal Na+,K+-ATPase activity is a phenomenon dependent on both age and type of diet. In young rats, it is the food intake that plays an important role in development of insensitivity of Na+,K+-ATPase to stimulation by 5-HT, while in adult animals fasting or fasting followed by refeeding does not play a major role in regulating its sensitivity to the amine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serotonina
/
Depuradores de Radicales Libres
/
Ayuno
/
ATPasa Intercambiadora de Sodio-Potasio
/
Ingestión de Alimentos
Límite:
Animals
Idioma:
En
Revista:
Acta Physiol Scand
Año:
2000
Tipo del documento:
Article
País de afiliación:
Portugal