Pretargeting with the affinity enhancement system for radioimmunotherapy.
Cancer Biother Radiopharm
; 14(3): 153-66, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10850300
ABSTRACT
The pretargeting technique referred to as the Affinity Enhancement System (AES) uses bispecific antibodies and radiolabeled bivalent haptens that bind cooperatively to target cells in vivo. Experimental and clinical data demonstrate that AES can deliver large radiation doses to tumor cells with high tumor to normal tissue contrast ratios and long activity residence time in tumors. Preliminary clinical results of radioimmunotherapy of medullary thyroid carcinomas and lung cancers look promising.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioinmunoterapia
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Biother Radiopharm
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
NEOPLASIAS
/
TERAPEUTICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia