The role of the oocyte in folliculogenesis.
Trends Endocrinol Metab
; 11(5): 193-8, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-10856922
ABSTRACT
Novel regulatory proteins have been identified within oocytes that are crucially involved in folliculogenesis. One of the most exciting oocyte signaling molecules is a novel member of the transforming growth factor beta (TGF-beta) superfamily, growth differentiation factor 9 (GDF-9). Loss-of-function studies have established that GDF-9 is obligatory for proper folliculogenesis and fertility in female mice. The current challenges are to understand how oocyte morphogens regulate folliculogenesis and how their actions and interactions are integrated into the overall processes of physiology and pathophysiology. Who would have thought that oocyte morphogens would be so crucial for reproduction?
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oocitos
/
Péptidos y Proteínas de Señalización Intercelular
/
Folículo Ovárico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Trends Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos