[Teratogenicity study of sodium chlorite in rats by oral administration].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku
; (117): 99-103, 1999.
Article
en Ja
| MEDLINE
| ID: mdl-10859940
ABSTRACT
The teratogenicity of sodium chlorite (NaClO2) was assessed in Wistar rats (Crj Wistar). Sodium chlorite dissolved in distilled water was given to pregnant Wistar rats by gavage once a day from day 6 through 15 of pregnancy at doses of 0, 25, 50 and 100 mg/kg/day. The pregnant rats were sacrificed on day 20 of pregnancy, and their fetuses were examined for malformations. Sodium chlorite caused decreased food consumption, anemia, sedation, hematuria, and death in the pregnant rats at 100 mg/kg, but no fetal effects, such as malformations or growth retardation, were observed even at 100 mg/kg. It was concluded that sodium chlorite has no teratogenicity in rats when administered orally. The no-observed-adverse-effect level was 50 mg/kg/day for pregnant rats and 100 mg/kg/day or more for rat fetuses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cloruros
Límite:
Animals
/
Pregnancy
Idioma:
Ja
Revista:
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku
Asunto de la revista:
MEDICINA
/
SAUDE PUBLICA
Año:
1999
Tipo del documento:
Article