Acute effects of gamma-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro.
Epilepsy Res
; 40(2-3): 99-107, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-10863137
ABSTRACT
Vigabatrin (gamma-vinyl-GABA, VGB) is a gamma-aminobutyric acid (GABA) derivative designed to boost synaptic inhibition by inhibiting the degradation of GABA in brain tissue. Indeed, VGB shows potent anti-convulsant activity in animal models of epilepsy and in humans with complex partial seizures. However, details of the mechanism of action of VGB are not well understood and the systemic effects include possible pro-convulsant actions. We therefore analysed the effects of VGB in rat brain slices in the low-Mg(2+) model in vitro. VGB at 100 microM-5 mM showed a concentration- and time-dependent reduction of interictal-like events in the hippocampal CA1 region. Likewise, VGB suppressed epileptiform discharges in the medial entorhinal cortex (mEC), which are known to resist conventional anti-convulsants. In contrast, evoked population spikes in CA1 (which became repetitive after washout Mg(2+)) were not altered by VGB. Our data show that VGB is efficient against epileptiform discharges in temporal structures including pharmacoresistant patterns of activity. The waveform of evoked population spikes in this in vitro model is no indicator for the anti-convulsant properties of drugs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Piramidales
/
Transmisión Sináptica
/
Vigabatrin
/
Anticonvulsivantes
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Epilepsy Res
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
HOLANDA
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HOLLAND
/
NETHERLANDS
/
NL
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PAISES BAJOS
/
THE NETHERLANDS