Effectiveness of bone cement containing tobramycin. An in vitro susceptibility study of 99 organisms found in infected joint arthroplasty.
J Bone Joint Surg Br
; 81(3): 440-3, 1999 May.
Article
en En
| MEDLINE
| ID: mdl-10872362
ABSTRACT
We used 99 strains of organisms representative of orthopaedic infections to examine the effectiveness of a bone cement containing tobramycin, employing a modified in vitro Kirby-Bauer susceptibility model. The spectrum was broad, including Gram-positive and Gram-negative aerobic organisms, anaerobes and mycobacteria. Simplex P with added tobramycin was effective against most of the strains, including those which are resistant to typical systemic levels of tobramycin. Although direct correlation between in vitro and in vivo results is difficult, the study showed that tobramycin is stable to the exothermic polymerisation of the cement, and that it is released from the surface of the cement at concentrations high enough to inhibit the growth of most organisms which may be encountered after joint arthroplasty.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteomielitis
/
Infección de la Herida Quirúrgica
/
Tobramicina
/
Infecciones Bacterianas
/
Cementos para Huesos
/
Metilmetacrilato
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Bone Joint Surg Br
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos