Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.
Dermatology
; 200(4): 331-3, 2000.
Article
en En
| MEDLINE
| ID: mdl-10894967
ABSTRACT
Muir-Torre syndrome is a genodermatosis in which multiple internal malignancies are associated with cutaneous sebaceous tumours and kerato-acanthomas. A 57-year-old man presented with multiple sebaceous tumours, kerato-acanthomas, verrucous carcinoma of the nose, renal cell and transitional cell carcinomas of the left kidney, adenoma of the colon and a positive family history of colon carcinoma. He was treated with interferon (IFN-alpha2a) s.c. 3 x 10(6) U three times a week along with 50 mg isotretinoin daily as well as topical isotretinoin gel. During a follow-up of 29 months, only 1 sebaceous skin tumour developed and was removed, whereas more than 30 such skin tumours had been surgically removed during the last 3 years. No evidence of internal tumour development or recurrence was found. The combination of IFN with retinoids seems to be of promise to prevent tumour development in Muir-Torre syndrome.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Sebáceas
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Neoplasias Primarias Múltiples
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dermatology
Asunto de la revista:
DERMATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania