Mutations in the gene for the IL-7 receptor result in T(-)B(+)NK(+) severe combined immunodeficiency disease.
Curr Opin Immunol
; 12(4): 468-73, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10899029
ABSTRACT
Recently, two SCID (severe combined immunodeficiency disease) patients with greatly diminished T cells but normal or increased numbers of B and NK cells (T(-)B(+)NK(+) SCID) were found to have mutations in the gene for the IL-7 receptor. This has established a major role for IL-7-receptor-dependent signaling in T cell development in humans and probably explains the diminished T cell numbers seen in patients with X-linked SCID or SCID that results from Jak3-deficiency.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunodeficiencia Combinada Grave
/
Receptores de Interleucina-7
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos