Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones.
Biochem Biophys Res Commun
; 274(1): 32-6, 2000 Jul 21.
Article
en En
| MEDLINE
| ID: mdl-10903891
ABSTRACT
Human glutathione transferase M2-2 prevents the formation of neurotoxic aminochrome and dopachrome by catalyzing the conjugation of dopamine and dopa o-quinone with glutathione. NMR analysis of dopamine and dopa o-quinone-glutathione conjugates revealed that the addition of glutathione was at C-5 to form 5-S-glutathionyl-dopamine and 5-S-glutathionyl-dopa, respectively. Both conjugates were found to be resistant to oxidation by biological oxidizing agents such as O(2), H(2)O(2), and O(*-)(2), and the glutathione transferase-catalyzed reaction can therefore serve a neuroprotective antioxidant function.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dihidroxifenilalanina
/
Dopamina
/
Benzoquinonas
/
Indolquinonas
/
Glutatión Transferasa
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2000
Tipo del documento:
Article
País de afiliación:
Chile