Localization of G-protein-coupled receptors in health and disease.
Trends Pharmacol Sci
; 21(8): 304-8, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10918636
ABSTRACT
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Superficie Celular
/
Proteínas de Unión al GTP
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos