The BRCA1 C-terminal domain: structure and function.
Mutat Res
; 460(3-4): 319-32, 2000 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-10946236
ABSTRACT
The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína BRCA1
/
Proteínas Supresoras de Tumor
/
Ubiquitina-Proteína Ligasas
Idioma:
En
Revista:
Mutat Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido