Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid.
Bioorg Med Chem
; 8(1): 239-46, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10968283
ABSTRACT
Some rigid analogues of flavone-8-acetic acid are described. Direct in vitro toxicity of the synthesised compounds was evaluated towards four tumoral cell lines and the ability of these compounds to stimulate mouse peritoneal macrophages in culture to become tumoricidal (indirect toxicity) was also studied. All compounds were able to induce direct cytotoxicity only at very high concentrations but showed a remarkable indirect activity. In particular compound 4d was able to significantly increase macrophage lytic properties and has been selected for further investigations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia