Demonstration and diagnostic significance of pro-gastrin-releasing peptide in medullary thyroid carcinoma.
Oncology
; 59(2): 122-5, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10971170
ABSTRACT
The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histological types (n = 12) were all negative for proGRP. In addition, serum proGRP levels were elevated in patients with primary or recurrent MTC (n = 3), and they changed in parallel with serum calcitonin (CT), and carcinoembryonic antigen (CEA). These results show that proGRP, which is considered to be a specific marker for small-cell lung carcinoma, may be also a potential tumor marker for MTC, in addition to CT and CEA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Péptidos
/
Proteínas Recombinantes
/
Neoplasias de la Tiroides
/
Biomarcadores de Tumor
/
Carcinoma Medular
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oncology
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón