Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?
J Environ Pathol Toxicol Oncol
; 19(3): 281-6, 2000.
Article
en En
| MEDLINE
| ID: mdl-10983894
ABSTRACT
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic carcinogenesis have not been established. Arsenic does not act through classic genotoxic and mutagenic mechanisms, as do other metals such as cadmium or chromium. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arsénico
/
Carcinógenos
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Environ Pathol Toxicol Oncol
Asunto de la revista:
NEOPLASIAS
/
PATOLOGIA
/
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos