Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin.
Contact Dermatitis
; 43(3): 137-43, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-10985629
ABSTRACT
There is increasing evidence of an interaction between the nervous and the immune systems. The aim of this study was to investigate the rôle of calcitonin gene-related peptide (CGRP) in the modulation of the elicitation of immediate and delayed, immunological and non-immunological reactions in human skin. CGRP (13 pmol and 39 pmol), and the CGRP-antagonist, CGRP/8-37/, (50 pmol and 500 pmol) were injected intracutaneously prior to provocation tests. Patients with allergy to nickel were provoked with nickel sulfate epicutaneously, and the reactions were evaluated by a clinical scoring system (guidelines of the International Contact Dermatitis Research Group). Patients with allergy to birch pollen were provoked by a prick test with the allergen, and the volume of the weals was measured. The patients were also provoked with tuberculin (delayed immunologic reaction), benzalkonium chloride (irritant contact dermatitis), UV-light and benzoic acid (non-immunologic contact urticaria). The test reactions were estimated by planimetry. CGRP/8-37/ exerted dual effects on allergic contact dermatitis, causing potentiation at a dose of 500 pmol (p= 0.004) and inhibition at a dose of 50 pmol (p=0.012). Other reactions were not significantly affected by the pretreatments. The results suggest that CGRP participates in delayed inflammatory reactions, but is not involved in immediate immunologic reactions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Relacionado con Gen de Calcitonina
/
Dermatitis por Contacto
/
Hipersensibilidad Inmediata
Tipo de estudio:
Guideline
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Contact Dermatitis
Año:
2000
Tipo del documento:
Article
País de afiliación:
Suecia