The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
Bioorg Med Chem Lett
; 10(17): 1949-52, 2000 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-10987424
ABSTRACT
The cyclic peptide ANP 4-23 and the linear peptide analogue AP-811 have been shown to be selective ANP-CR antagonists. Via alanine scanning and truncation studies we sought to determine which residues in these molecules were important in their binding to the clearance receptor and the relationship between these two molecules. These studies show that several modifications to these compounds are possible which improve physical properties of these molecules while retaining high affinity for the ANP-CR.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor Natriurético Atrial
/
Receptores del Factor Natriurético Atrial
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos