D-amphetamine facilitation of morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex.
Behav Brain Res
; 114(1-2): 135-43, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-10996054
ABSTRACT
The effect of posttraining D-amphetamine on Morris water task (MWT) performance was analyzed in this study by training rats using a single training trial per day procedure. In addition to acquisition latency, learning was assessed by a probe trial given 24 h after the last training trial. Rats given immediate post-trial D-amphetamine demonstrated improved performance over saline rats on both acquisition and the probe trial. An analysis of the mechanisms underlying facilitation revealed that eticlopride (a D2 antagonist) blocked D-amphetamine's facilitatory effects on the probe trial and dopamine synthesis was increased in the medial prefrontal cortex in the D-amphetamine group relative to controls. These results show that chronic administration of posttraining D-amphetamine facilitated MWT performance, and this facilitation may be mediated by the dopaminergic system and dopamine synthesis in the prefrontal cortex.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dopamina
/
Salicilamidas
/
Corteza Prefrontal
/
Aprendizaje por Laberinto
/
Antagonistas de Dopamina
/
Dextroanfetamina
/
Estimulantes del Sistema Nervioso Central
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Canadá