Investigation of drug release from suspension using FTIR-ATR technique: part II. Determination of dissolution coefficient of drugs.
Int J Pharm
; 204(1-2): 151-8, 2000 Aug 25.
Article
en En
| MEDLINE
| ID: mdl-11011999
ABSTRACT
Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy was applied to a release experiment in order to determine the dissolution coefficient of drug particles in heterogeneous semisolid formulations. The drug release experiment was carried out using ketoconazole suspended in Vaseline with various amounts of paraffinum liquidum as donor and an artificial dodecanol-collodion (DDC) membrane as acceptor compartment. Monitoring changes in IR bands due to ketoconazole the decrease of the drug content near the ATR crystal ointment was followed as a function of time. A mathematical model based on Fick's second law with a source term was used to derive the apparent dissolution coefficient Kdis by numerical fitting the experimental data. It was found that Kdis is dependent on the fraction of paraffinum liquidum in the suspension. Taking into account all experimental parameters required, the transport process was simulated and discussed in terms of drug concentration- time and drug concentration- distance profiles. Calculating the area under the mass-time curve it was tried to predict the 'dermal bioavailability' in the acceptor (AUCa).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vaselina
/
Emolientes
/
Cetoconazol
/
Modelos Químicos
/
Antifúngicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Pharm
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania