Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease.
Neurobiol Aging
; 21(5): 729-34, 2000.
Article
en En
| MEDLINE
| ID: mdl-11016542
ABSTRACT
Alterations in calcium homeostasis might be implicated in the neuropathology of Alzheimer's disease (AD). To date it is not clear whether changes in cytosolic calcium level ([Ca2+ ]i) are the result or the cause of pathogenic effects. In platelets of patients with early stages of AD, the basal values of [Ca2+]i in the absence of extracellular Ca2+ were significantly lower in comparison with age-matched and young controls. After the addition of 1 mM calcium into the incubation medium the [Ca2+]i markedly increased in platelets of AD patients whereas the increase only to a smaller extent was observed in control age-matched and young subjects. The present study proposes that calcium dysregulation during the whole disease period could not be uniform and according to our results the [Ca2+]i is reduced in the first stages of AD. We suggest that the disturbed calcium homeostasis in AD is an "early defect."
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Calcio
/
Enfermedad de Alzheimer
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurobiol Aging
Año:
2000
Tipo del documento:
Article
País de afiliación:
República Checa